CALL FOR PAPERS Physiology and GI Cancer Experimental models for Barrett’s esophagus and esophageal adenocarcinoma
نویسندگان
چکیده
Katherine S. Garman, Roy C. Orlando, and Xiaoxin Chen Division of Gastroenterology, Department of Medicine, Duke University and Durham Veterans Affairs Medical Center, Durham; Division of Gastroenterology and Hepatology, Center for Esophageal Diseases and Swallowing, University of North Carolina at Chapel Hill, Chapel Hill; and Cancer Research Program, Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, North Carolina
منابع مشابه
Meta-Analysis The Incidence of Esophageal Cancer and High-Grade Dysplasia in Barrett’s Esophagus: A Systematic Review and Meta-Analysis
Barrett’s esophagus is a well-recognized precursor of esophageal adenocarcinoma. Surveillance of Barrett’s esophagus patients is recommended to detect high-grade dysplasia (HGD) or early cancer. Because of wide variation in the published cancer incidence in Barrett’s esophagus, the authors undertook a systematic review and meta-analysis of cancer and HGD incidence in Barrett’s esophagus. Ovid M...
متن کاملAclinicopathological survey of esophageal cancer in patients referred to a gastroenterology clinic in Tehran, 1991-2005
Abstract Background: Esophageal cancer is one of the major malignancies, with various epidemiological aspects in recent years in developing countries, including increased prevalence and variations of pathologic patterns. This may be due to increasing rates of Barrett’s esophagus, gastroesophageal reflux, smoking and obesity. This study was performed from 1991 to 2005 in order to evaluate vario...
متن کاملCCR New Strategies New Strategies in Barrett's Esophagus: Integrating Clonal Evolutionary Theory with Clinical Management
Barrett’s esophagus is a condition in which the normal stratified squamous epithelium of the distal esophagus is replaced by intestinal metaplasia. For more than three decades, the prevailing clinical paradigm has been that Barrett’s esophagus is a complication of symptomatic reflux disease that predisposes to esophageal adenocarcinoma. However, no clinical strategy for cancer prevention or ear...
متن کاملNull Results in Brief No Association between hOGG1, XRCC1, and XPD Polymorphisms and Risk of Reflux Esophagitis, Barrett’s Esophagus, or Esophageal Adenocarcinoma: Results from the Factors Influencing the Barrett’s Adenocarcinoma Relationship Case-Control Study
Reflux of gastric contents can lead to development of reflux esophagitis and Barrett’s esophagus. Barrett’s esophagus is a risk factor for esophageal adenocarcinoma. Damage to DNA may lead to carcinogenesis but is repaired through activation of pathways involving polymorphic enzymes, including human 8-oxoguanine glycosylase 1 (hOGG1), X-ray repair cross-complementing 1 (XRCC1), and xeroderma pi...
متن کاملEDITORIALS Cyclooxygenase-2 Inhibitor Therapy for the Prevention of Esophageal Adenocarcinoma in Barrett’s Esophagus
The outcome for patients diagnosed with esophageal adenocarcinoma remains abysmal despite a better understanding of the molecular events that underlie development of the disease. Additionally, the incidence for this type of esophageal carcinoma has been rapidly increasing in the United States over the last three decades (1). Esophageal adenocarcinoma often occurs in the setting of Barrett’s eso...
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تاریخ انتشار 2012